It's T Time for Normal Blood Vessels

Bernard Thienpont; Diether Lambrechts

doi:10.1016/j.devcel.2017.04.005

It's T Time for Normal Blood Vessels

Dev Cell. 2017 Apr 24;41(2):125-126. doi: 10.1016/j.devcel.2017.04.005.

Authors

Bernard Thienpont¹, Diether Lambrechts²

Affiliations

¹ Center for Cancer Biology, VIB, 3000 Leuven, Belgium; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium. Electronic address: bernard.thienpont@vib-kuleuven.be.
² Center for Cancer Biology, VIB, 3000 Leuven, Belgium; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium. Electronic address: diether.lambrechts@kuleuven.vib.be.

PMID: 28441526
DOI: 10.1016/j.devcel.2017.04.005

Abstract

In a new report in Nature, Tian and colleagues (2017) describe that T cell activation in tumors induces blood vessel normalization. Because abnormal vasculature in tumors is known to reduce chemotherapy effectiveness and T lymphocyte infiltration and to increase metastasis, this suggests an exciting novel angle for checkpoint immunotherapy.

Publication types

Review
Comment

MeSH terms

Animals
Drug Therapy* / methods
Humans
Immunotherapy*
Neoplasm Metastasis / immunology*
Neoplasm Metastasis / pathology
Neoplasms / blood supply*
Neovascularization, Pathologic / physiopathology*
T-Lymphocytes / cytology*
T-Lymphocytes / immunology