Sex differences in the association between area deprivation and generalised anxiety disorder: British population study

BMJ Open. 2017 May 4;7(5):e013590. doi: 10.1136/bmjopen-2016-013590.

Abstract

Objective: Studies have shown that area-level deprivation measured by factors, such as non-home ownership, non-car ownership and household overcrowding, can increase the risk for mental disorders over and above individual-level circumstances, such as education and social class. Whether area-level deprivation is associated with generalised anxiety disorder (GAD) independent of personal circumstances, and whether this association is different between British women and men is unknown.

Design: Large, population study.

Setting: UK population-based cohort.

Participants: 30 445 people from the general population aged 40 years and older and living in England consented to participate at study baseline, and of these, 21 921 participants completed a structured health and lifestyle questionnaire used to capture GAD. Area deprivation was measured in 1991 using Census data, and GAD was assessed in 1996-2000. 10 275 women and 8219 men had complete data on all covariates.

Main outcome measure: Past-year GAD defined according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV).

Results: In this study, 2.5% (261/10 275) of women and 1.8% (145/8219) of men had GAD. Women living in the most deprived areas were over 60% more likely to develop anxiety than those living in areas that were not deprived (OR=1.63, 95% CI 1.21 to 2.21; p=0.001), but this association between deprivation and GAD was not apparent in men (OR=1.13, 95% CI 0.72 to 1.77; p=0.598).

Conclusions: The absolute numbers of people living in deprived conditions are large worldwide. This, combined with a growing mental health burden, means that the findings obtained in this study remain highly relevant. The WHO has emphasised the need to reduce social and health inequalities. Our findings provide a strong evidence base to this call, showing that the environment needs to be taken into account when developing mental health policy; gender is important when it comes to assessing the influence of the environment on our mental health.

Keywords: EPIDEMIOLOGY; MENTAL HEALTH; PUBLIC HEALTH.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anxiety Disorders / epidemiology*
  • Anxiety Disorders / etiology
  • England / epidemiology
  • Female
  • Health Status Disparities
  • Health Surveys
  • Humans
  • Male
  • Middle Aged
  • Population Surveillance / methods*
  • Poverty Areas*
  • Prevalence
  • Risk Factors
  • Sex Factors
  • Socioeconomic Factors
  • Surveys and Questionnaires