Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study

Thor Ueland; Lars E Laugsand; Lars J Vatten; Imre Janszky; Carl Platou; Annika E Michelsen; Jan K Damås; Pål Aukrust; Bjørn O Åsvold

doi:10.1016/j.ijcard.2017.05.106

Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study

Int J Cardiol. 2017 Sep 15:243:502-504. doi: 10.1016/j.ijcard.2017.05.106. Epub 2017 Jun 12.

Authors

Thor Ueland¹, Lars E Laugsand², Lars J Vatten³, Imre Janszky⁴, Carl Platou⁵, Annika E Michelsen⁶, Jan K Damås⁷, Pål Aukrust⁸, Bjørn O Åsvold⁹

Affiliations

¹ Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway; K.G. Jebsen TREC, University of Tromsø, Tromsø, Norway. Electronic address: thor.ueland@medisin.uio.no.
² Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Cardiology, St. Olavs Hospital, Trondheim, Norway.
³ Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
⁴ Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
⁵ Department of Internal Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.
⁶ Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
⁷ Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Infectious Diseases, St. Olavs Hospital, Trondheim, Norway.
⁸ Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway; K.G. Jebsen TREC, University of Tromsø, Tromsø, Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway.
⁹ Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Endocrinology, St. Olavs Hospital, Trondheim, Norway.

PMID: 28615143
DOI: 10.1016/j.ijcard.2017.05.106

Abstract

Background: We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals.

Methods: Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control study nested within the population-based HUNT2 cohort in Norway. Among 58,761 apparently healthy men and women followed a median 11.3years, 1587 incident MI cases were registered, and compared to 3959 age- and sex-matched controls.

Results: Higher serum sCD163 (Q4 vs. Q1 OR: 1.27, P-trend 0.002), sCD14 (Q4 vs. Q1 OR: 1.38, P-trend<0.001), and especially sCD25 (Q4 vs. Q1 OR: 1.45, P-trend<0.001), were associated with increased MI risk in the age-and sex adjusted models. However, after additional adjustment for cardiovascular risk factors these associations were strongly attenuated (Q4 vs Q1 ORs between 1.02 and 1.12, P-trends between 0.30 and 0.58).

Conclusions: sCD163, sCD14 and sCD25 may reflect leukocyte activation and inflammatory mechanisms related to atherogenesis, but do not predict MI risk above and beyond conventional cardiovascular risk factors.

Keywords: Leukocyte markers; Myocardial infarction.

MeSH terms

Aged
Aged, 80 and over
Biomarkers / blood
Case-Control Studies
Female
Follow-Up Studies
Humans
Macrophages / metabolism*
Male
Middle Aged
Monocytes / metabolism*
Myocardial Infarction / blood*
Myocardial Infarction / diagnosis*
Myocardial Infarction / epidemiology
Norway / epidemiology
Risk Factors
T-Lymphocytes / metabolism*

Substances

Biomarkers