Differentiation of low- and high-grade clear cell renal cell carcinoma: Tumor size versus CT perfusion parameters

Abstract

Purpose: To compare the utility of tumor size and CT perfusion parameters for differentiation of low- and high-grade clear cell renal cell carcinoma (RCC).

Materials and methods: Tumor size, Equivalent blood volume (Equiv BV), permeability surface-area product (PS), blood flow (BF), and Fuhrman pathological grading of clear cell RCC were retrospectively analyzed.

Results: High-grade clear cell RCC had significantly higher tumor size and lower PS than low grade. Tumor size positively correlated with Fuhrman grade, but PS negatively did.

Conclusions: Tumor size and PS were significantly independent indexes for differentiating high-grade from low-grade clear cell RCC.

Keywords: Clear cell renal cell carcinoma; Computed tomography; Fuhrman grade; Perfusion imaging; Size.