Mechanisms of fosfomycin resistance in carbapenem-resistant Enterobacter sp

Int J Antimicrob Agents. 2017 Nov;50(5):690-692. doi: 10.1016/j.ijantimicag.2017.05.010. Epub 2017 Jul 5.

Abstract

We report on fosfomycin susceptibility and mechanisms of resistance in clinical strains of blaKPC-positive Enterobacter sp. (n = 19). A total of 14 strains (74%) were susceptible to fosfomycin; 8 strains (42%) were positive for fosA and no strains were positive for FosA3 or FosC2. FosA presence does not appear to correlate with susceptibility.

Keywords: Antibiotic resistance; Antimicrobial activity; Antimicrobial agents; Beta-lactamases; Clinical therapeutics; Gram-negative bacteria.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / metabolism
  • Drug Resistance, Bacterial*
  • Enterobacter / drug effects*
  • Enterobacter / enzymology
  • Enterobacter / genetics
  • Enterobacter / isolation & purification
  • Fosfomycin / pharmacology*
  • Genes, Bacterial
  • Humans
  • Prospective Studies
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Fosfomycin
  • beta-Lactamases
  • carbapenemase