Microvascular dysfunction in infiltrative cardiomyopathies

J Nucl Cardiol. 2019 Feb;26(1):200-207. doi: 10.1007/s12350-017-0991-z. Epub 2017 Jul 11.

Abstract

Infiltrative heart diseases are characterized by myocardial tissue alterations leading to mechanical dysfunction which in turn develops into bi-ventricular congestive heart failure. Also the coronary microvasculature undergoes significant remodeling and dysfunction. The effects of the unbalance of the mechanical cross-talk between cardiac muscle and vessels and of the impairment of vasodilatory function can be measured non-invasively by means of positron emission tomography and cardiac magnetic resonance.

Keywords: Coronary artery disease; cardiomyopathy; coronary blood flow; vasodilator stress.

Publication types

  • Review

MeSH terms

  • Arterioles / pathology
  • Cardiomyopathies / pathology*
  • Coronary Circulation*
  • Coronary Vessels / physiopathology
  • Fabry Disease / pathology
  • Female
  • Heart / physiology
  • Heart Failure / pathology
  • Humans
  • Male
  • Microcirculation*
  • Microvessels / physiopathology
  • Myocardium / pathology*
  • Oxidative Stress
  • Positron-Emission Tomography
  • Sarcoidosis / pathology
  • Tomography, X-Ray Computed