RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance

Trends Cancer. 2016 Apr;2(4):191-204. doi: 10.1016/j.trecan.2016.03.002. Epub 2016 Apr 4.

Abstract

Ribosomal biogenesis is tightly associated with cellular activities, such as growth, proliferation, and cell cycle progression. Perturbations in ribosomal biogenesis can initiate so-called nucleolar stress. The process through which ribosomal proteins (RPs) transduce nucleolar stress signals via MDM2 to p53 has been described as a crucial tumor-suppression mechanism. In this review we focus on recent progress pertaining to the function and mechanism of RPs in association with the MDM2-p53 tumor-suppression network, and the potential implications this surveillance network has for cancer development.

Keywords: MDM2; cancer; p53; ribosomal protein.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Neoplasms / metabolism*
  • Proto-Oncogene Proteins c-mdm2 / metabolism*
  • Ribosomal Proteins / metabolism*
  • Signal Transduction
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Ribosomal Proteins
  • Tumor Suppressor Protein p53
  • Proto-Oncogene Proteins c-mdm2