Impact of Exercise Training on Peak Oxygen Uptake and its Determinants in Heart Failure with Preserved Ejection Fraction

Wesley J Tucker; Michael D Nelson; Rhys I Beaudry; Martin Halle; Satyam Sarma; Dalane W Kitzman; Andre La Gerche; Mark J Haykowksy

doi:10.15420/cfr.2016:16:2

Impact of Exercise Training on Peak Oxygen Uptake and its Determinants in Heart Failure with Preserved Ejection Fraction

Card Fail Rev. 2016 Nov;2(2):95-101. doi: 10.15420/cfr.2016:16:2.

Authors

Wesley J Tucker¹, Michael D Nelson¹, Rhys I Beaudry¹, Martin Halle², Satyam Sarma^{3

4}, Dalane W Kitzman⁵, Andre La Gerche⁶, Mark J Haykowksy^{1

6}

Affiliations

¹ College of Nursing and Health Innovation, University of Texas at Arlington, Arlington,Texas, USA.
² Technical University Munich,Munich, Germany.
³ Institute for Exercise and Environmental Medicine,Texas Health Presbyterian Hospital, Dallas.
⁴ University of Texas Southwestern Medical Center,Dallas, Texas, USA.
⁵ Wake Forest School of MedicineWinston-Salem, North Carolina, USA.
⁶ Sport Cardiology, Baker IDI Heart Institute,Melbourne, Victoria, Australia.

Abstract

Heart failure with preserved ejection (HFpEF) accounts for over 50 % of all HF cases, and the proportion is higher among women and older individuals. A hallmark feature of HFpEF is dyspnoea on exertion and reduced peak aerobic power (VO_2peak) secondary to central and peripheral abnormalities that result in reduced oxygen delivery to and/or utilisation by exercising skeletal muscle. The purpose of this brief review is to discuss the role of exercise training to improve VO_2peak and the central and peripheral adaptations that reduce symptoms following physical conditioning in patients with HFpEF.

Keywords: Heart failure with preserved ejection fraction; exercise training; peak aerobic power.