Prothrombin fragment F1+2 in plasma and urine during total hip arthroplasty

Pål O Borgen; Olav Reikeras

doi:10.1016/j.jor.2017.08.001

Prothrombin fragment F1+2 in plasma and urine during total hip arthroplasty

J Orthop. 2017 Aug 3;14(4):475-479. doi: 10.1016/j.jor.2017.08.001. eCollection 2017 Dec.

Authors

Pål O Borgen¹, Olav Reikeras²

Affiliations

¹ Department of Orthopedics, Martina Hansens Hospital, Norway.
² Department of Orthopedics, Oslo University Hospital, Rikshospitalet, Norway.

Abstract

Objective: To study the time course and correlation of prothrombin fragment (F1 + 2) in plasma and urine during THA.

Method: F1 + 2 concentrations were recorded at four time-points during THA.

Results: F1 + 2 increased during surgery. In contrast to urine, plasma F1 + 2 was temporarily reduced the first postoperative day. At day six, plasma F1 + 2 was significantly elevated indicating on-going thrombin activation, while urine F1 + 2 was normalized.

Conclusion: The response in coagulation to operative trauma can be recorded with F1 + 2 both in plasma and urine. We were not able to demonstrate any correlation of F1 + 2 in plasma and urine later in the postoperative period.

Keywords: Biomarkers; Prophylaxis; Thrombosis; Total hip arthroplasty.