Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

Sibel Z Aydin; Haner Direskeneli; Peter A Merkel; International Delphi on Disease Activity Assessment in Large-vessel Vasculitis

doi:10.3899/jrheum.161269

Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

J Rheumatol. 2017 Dec;44(12):1928-1932. doi: 10.3899/jrheum.161269. Epub 2017 Sep 1.

Authors

Sibel Z Aydin^{1

2}, Haner Direskeneli^{1

2}, Peter A Merkel^{3

4}; International Delphi on Disease Activity Assessment in Large-vessel Vasculitis

Collaborators

International Delphi on Disease Activity Assessment in Large-vessel Vasculitis:
Steven Ytterberg, Daniel Blockmans, Emilia Inoue Sato, Alexandre Wagner Silva de Souza, David Cabral, Simon Carette, Leilani Famorca, Nader Khalidi, Nataliya Milman, Elaine Yacyshyn, Vladimir Tesar, Bo Baslund, Mikkel Faurschou, Loïc Guillevin, Xavier Puéchal, Peer Aries, Bernhard Hellmich, Karen Herlyn, Julia Holle, Peter Lamprecht, Frank Moosig, Thomas Neumann, Jochen Zwerina, Gunnar Tómasson, Pradeep Bambery, Ramesh Jois, Liza Rajasekhar, Aman Sharma, Rajappa Sivakumar, Eamonn Molloy, Philip Hashkes, Fausta Catapano, Luca Cimino, Alessandro de Fanti, Nicolo Pipitone, Carlo Salvarani, Augusto Vaglio, Shigeto Kobayashi, Kazuo Suzuki, Luis Felipe Flores-Suárez, Andrea Hinojosa-Azaola, Elisabeth Brouwer, Abraham Rutgers, Coen Stegeman, Ravi Suppiah, Ivana Hollan, Pedro Arguis, Maria C Cid, Thomas Daikeler, Fatma Alibaz-Oner, Vedat Hamuryudan, Gulen Hatemi, Tuncay Hazirolan, Murat Inanc, Muge Bicakcigil Kalayci, Sevil Kamali, Tulay Kansu, Yaşar Karaaslan, Omer Karadag, Gokhan Keser, Ahmet Mesut Onat, Zeynep Ozbalkan, Seza Ozen, Hüseyin Te Ozer, Ömer Nuri Pamuk, Suzan Guven Yilmaz, Neil Basu, Alina Casian, Kuntal Chakravarty, David D'Cruz, Clive Edelsten, Lorraine Harper, David Jayne, Jeremy Levy, Justin Mason, Joanna Robson, David Scott, Miles Stanford, Richard Watts, Daniel Albert, Naomi Amudala, Joshua Beckman, Marcus Both, Billy Chacko, Sharon Chung, Barri Fessler, Alexandra Giardino, Peter Grayson, Gene Hunder, Carol Langford, Melissa Lerman, Kimberly Liang, Harold Litt, Tom Mason, Eric Matteson, Jamal Mikdashi, Emile Mohler, Paul Monach, Brian Rice, Aditya Sharma, Antoine Sreih, John Stone, Nicholas Tsapatsaris, Alexandra Villa-Forte, Kenneth Warrington, Yusuf Yazici, Sergio Toloza

Affiliations

¹ From the Division of Rheumatology, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada; Division of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey; Division of Rheumatology, and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
² S.Z. Aydin, MD, Associate Professor, Division of Rheumatology, The Ottawa Hospital Research Institute, University of Ottawa; H. Direskeneli, MD, Professor of Rheumatology, Division of Rheumatology, Marmara University Faculty of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology, and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania.
³ From the Division of Rheumatology, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada; Division of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey; Division of Rheumatology, and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA. pmerkel@upenn.edu.
⁴ S.Z. Aydin, MD, Associate Professor, Division of Rheumatology, The Ottawa Hospital Research Institute, University of Ottawa; H. Direskeneli, MD, Professor of Rheumatology, Division of Rheumatology, Marmara University Faculty of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology, and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. pmerkel@upenn.edu.

Abstract

Objective: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials.

Methods: A Delphi survey including 99 items was circulated among international experts for 3 rounds.

Results: Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging.

Conclusion: This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

Keywords: GIANT CELL ARTERITIS; LARGE VESSEL; OUTCOMES; TAKAYASU ARTERITIS; VASCULITIS.

MeSH terms

Delphi Technique
Giant Cell Arteritis / diagnosis*
Humans
Severity of Illness Index
Takayasu Arteritis / diagnosis*

Abstract

MeSH terms

Grants and funding