A zebrafish homologue of the murine Hox-2.1 gene

FEBS Lett. 1988 Mar 28;230(1-2):25-30. doi: 10.1016/0014-5793(88)80634-3.

Abstract

Homeobox-containing sequences were isolated from a genomic library of zebrafish (Brachydanio rerio). A lambda clone containing two homeobox cross-hybridizing regions was characterized. DNA sequencing of one of these regions (ZF-21) revealed that it contains a homeobox closely related to the Antennapedia class of Drosophila homeobox sequences. Moreover, the deduced amino acid sequence of the C-terminal end (81 residues including the homeobox) is identical to the corresponding part of the murine Hox-2.1 protein. Similar to Hox-2.1, a ZF-21 derived transcript of 2.3 kb is present in embryos at the somite forming stages.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacteriophage lambda / genetics
  • Base Sequence
  • Cyprinidae / genetics*
  • DNA / genetics
  • DNA, Recombinant
  • Drosophila melanogaster / genetics
  • Gene Expression Regulation
  • Genes, Homeobox*
  • Mice
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic
  • Zebrafish / embryology
  • Zebrafish / genetics*

Substances

  • DNA, Recombinant
  • DNA

Associated data

  • GENBANK/X07381