Germline Genome Protection on an Evolutionary Treadmill

Dev Cell. 2017 Oct 9;43(1):1-3. doi: 10.1016/j.devcel.2017.09.021.

Abstract

Preservation of genome integrity is a conserved, essential function, yet genome defense machinery evolves rapidly. In this issue of Developmental Cell, Parhad et al. (2017) harness an evolution-guided approach to define the genetic determinants of genome defense and to reveal the molecular and cellular mechanisms shaped by adaptive evolution.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Gene Expression / genetics
  • Gene Expression / immunology*
  • Genome / genetics*
  • Genome / immunology
  • Germ Cells* / immunology
  • Host-Pathogen Interactions / immunology*
  • Humans
  • RNA

Substances

  • RNA