An update on the incidence of perioperative outcomes after carotid endarterectomy, stratified by type of preprocedural neurologic symptom

J Vasc Surg. 2018 Mar;67(3):785-792. doi: 10.1016/j.jvs.2017.07.132. Epub 2017 Oct 23.

Abstract

Objective: Perioperative complications after carotid endarterectomy (CEA) have decreased over time. Therefore, we aimed to provide an update on 30-day outcomes after CEA, stratified by type of preprocedural neurologic symptom.

Methods: We included all CEAs from the Targeted Vascular module of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP, 2011-2015) and stratified patients based on type of preprocedural neurologic symptom, that is, asymptomatic, ocular transient ischemic attack (TIA), hemispheric TIA, and stroke. We compared 30-day outcomes across the groups, with 30-day stroke/death as our primary endpoint.

Results: Of 16,739 CEA patients, 9784 were asymptomatic (58%). Among the 6955 symptomatic patients, 1216 (17%) had a preprocedural ocular TIA, 2635 (38%) a preprocedural hemispheric TIA, and 3104 (45%) a preprocedural stroke. Preprocedural stroke patients had higher 30-day stroke/death rates compared with those with a preprocedural hemispheric TIA, or ocular TIA, or asymptomatic patients (5.0% vs 3.3%, 1.9%, and 1.8%, respectively; all P < .001), primarily owing to differences in perioperative 30-day stroke rates, with 4.1% vs 2.5%, 1.4%, and 1.3%, respectively (all P < .001).

Conclusions: Among symptomatic CEA patients, those with a preprocedural stroke had a high perioperative 30-day stroke/death rate, compared with those patients with either a preprocedural hemispheric or ocular TIA. Therefore, the common stratification applied to CEA patients, which groups all symptomatic patients, should be avoided, especially as the relative proportion of symptomatic patients with a preprocedural stroke vs those with a hemispheric or ocular TIA will affect the overall outcome for all symptomatic patients after CEA.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amaurosis Fugax / diagnostic imaging
  • Amaurosis Fugax / epidemiology*
  • Amaurosis Fugax / mortality
  • Asymptomatic Diseases
  • Carotid Artery Diseases / diagnostic imaging
  • Carotid Artery Diseases / epidemiology
  • Carotid Artery Diseases / surgery*
  • Databases, Factual
  • Endarterectomy, Carotid / adverse effects*
  • Endarterectomy, Carotid / mortality
  • Female
  • Humans
  • Incidence
  • Ischemic Attack, Transient / diagnostic imaging
  • Ischemic Attack, Transient / epidemiology*
  • Ischemic Attack, Transient / mortality
  • Male
  • Middle Aged
  • Registries
  • Retrospective Studies
  • Risk Factors
  • Stroke / diagnostic imaging
  • Stroke / epidemiology*
  • Stroke / mortality
  • Time Factors
  • Treatment Outcome
  • United States / epidemiology