Associations of lifestyle factors with serum dehydroepiandrosterone sulphate and insulin-like growth factor-1 concentration in prepubertal children

Aino Mäntyselkä; Jarmo Jääskeläinen; Aino-Maija Eloranta; Juuso Väistö; Raimo Voutilainen; Ken Ong; Søren Brage; Timo A Lakka; Virpi Lindi

doi:10.1111/cen.13511

Associations of lifestyle factors with serum dehydroepiandrosterone sulphate and insulin-like growth factor-1 concentration in prepubertal children

Clin Endocrinol (Oxf). 2018 Feb;88(2):234-242. doi: 10.1111/cen.13511. Epub 2017 Nov 29.

Authors

Aino Mäntyselkä¹, Jarmo Jääskeläinen¹, Aino-Maija Eloranta², Juuso Väistö^{2

3}, Raimo Voutilainen¹, Ken Ong⁴, Søren Brage⁴, Timo A Lakka^{2

5

6}, Virpi Lindi²

Affiliations

¹ Department of Pediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
² Department of Physiology, Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
³ Institute of Dentistry, School of Medicine, University of Eastern Finland, Kuopio, Finland.
⁴ MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
⁵ Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
⁶ Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.

Abstract

Objective: Little is known about the relationships of dietary factors, physical activity and sedentary behaviour to dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEAS and IGF-1 in children.

Design and subjects: Cross-sectional analysis of a population sample of 431 prepubertal children aged 6-9 years.

Measurements: Assessment of dietary factors by food records and physical activity and sedentary behaviour by a combined heart rate and movement monitor and a questionnaire. Measurement of serum DHEAS and IGF-1.

Results: Consumption of low-fibre grain products (standardized regression coefficient β = .118, P = .017) and intake of vegetable protein (β = .100, P = .045) was positively and consumption of sugar-sweetened beverages (β = -.117, P = .018) was inversely associated with DHEAS after adjustment for sex, age and body fat percentage. Energy intake (β = .160, P = .001) was positively associated with IGF-1 adjusting for sex, age and body fat percentage. Vigorous physical activity was inversely associated with DHEAS after adjustment for sex and age (β = -.120, P = .027), and total (β = -.137, P = .007), moderate (β = -.130, P = .012), vigorous (β = -.136, P = .011) and moderate to vigorous physical activity (β = -.160, P = .003) were inversely and total sedentary behaviour (β = .151, P = .003) was positively associated with IGF-1 adjusting for sex and age. None of physical activity measures was associated with DHEAS or IGF-1 after additional adjustment for body fat percentage.

Conclusions: Lifestyle factors have weak and moderate associations with biochemical markers of adrenarche in prepubertal children. These associations indicate body fat independent and dependent influences of diet and physical activity, respectively.

Trial registration: ClinicalTrials.gov NCT01803776.

Keywords: body fat percentage; dehydroepiandrosterone sulphate; insulin-like growth factor-1; lean body mass; lifestyle factors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Body Composition / physiology
Body Size / physiology
Child
Cross-Sectional Studies
Dehydroepiandrosterone Sulfate / blood*
Exercise / physiology
Female
Humans
Insulin-Like Growth Factor I / metabolism*
Male
Sedentary Behavior
Surveys and Questionnaires

Associations of lifestyle factors with serum dehydroepiandrosterone sulphate and insulin-like growth factor-1 concentration in prepubertal children

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