Vitamin D Metabolism and the Implications for Atherosclerosis

Adv Exp Med Biol. 2017:996:185-192. doi: 10.1007/978-3-319-56017-5_15.

Abstract

Vitamin D levels and metabolism may play a role in the pathogenesis and treatment of atherosclerosis and subsequent cardiovascular health. Herein, we discuss both normal and disordered vitamin D metabolism as it pertains to atherosclerosis, and we review major clinical trials regarding vitamin D levels and effects of supplementation. Although there are no official recommendations for vitamin D as it applies to atherosclerosis, it is clear that these two entities are linked. Further study of the complex association between vitamin D and atherosclerosis, as well as the effects of supplementation, are recommended.

Keywords: Atherosclerosis; Disclosures; Inflammation; No relevant disclosures; Vitamin D; Vitamin D deficiency.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteries / drug effects
  • Arteries / metabolism*
  • Arteries / pathology
  • Atherosclerosis / epidemiology
  • Atherosclerosis / metabolism*
  • Atherosclerosis / prevention & control
  • Dietary Supplements
  • Humans
  • Inflammation Mediators / metabolism
  • Plaque, Atherosclerotic
  • Risk Factors
  • Vitamin D / metabolism*
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency / drug therapy
  • Vitamin D Deficiency / epidemiology
  • Vitamin D Deficiency / metabolism*

Substances

  • Inflammation Mediators
  • Vitamin D