Optimal blood pressure control after coronary events: the challenge remains

J Am Soc Hypertens. 2017 Dec;11(12):823-830. doi: 10.1016/j.jash.2017.10.007. Epub 2017 Oct 28.

Abstract

We identified sociodemographic, medical, and psychosocial factors associated with unfavorable blood pressure (BP) control in 1012 patients, hospitalized with myocardial infarction and/or a coronary revascularization procedure. This cross-sectional study collected data from hospital records, a comprehensive self-report questionnaire, clinical examination, and blood samples after 2-36 (mean 17) months follow-up. Forty-six percent had unfavorable BP control (≥140/90 [80 in diabetics] mm Hg) at follow-up. Low socioeconomic status and psychosocial factors did not predict unfavorable BP control. Patients with unfavorable BP used on average 1.9 (standard deviation 1.1) BP-lowering drugs at hospital discharge, and the proportion of patients treated with angiotensin inhibitors and beta-blockers decreased significantly (P < .001) from discharge to follow-up. Diabetes (odds ratio [OR] 2.4), higher body mass index (OR 1.05 per 1.0 kg/m2), and older age (OR 1.04 per year) were significantly associated with unfavorable BP control in adjusted analyses. Only age (standardized beta [β] 0.24) and body mass index (β 0.07) were associated with systolic BP in linear analyses. We conclude that BP control was insufficient after coronary events and associated with obesity and diabetes. Prescription of BP-lowering drugs in hypertensive patients seems suboptimal. Overweight and intensified drug treatment thus emerge as the major factors to target to improve BP control.

Keywords: Antihypertensive treatment; medical factors; psychosocial factors; secondary prevention.

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Age Factors
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure / drug effects*
  • Blood Pressure Determination
  • Cross-Sectional Studies
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / physiopathology
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension / blood
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Hypertension / psychology
  • Male
  • Medication Adherence / statistics & numerical data
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / physiopathology
  • Myocardial Infarction / psychology
  • Myocardial Infarction / therapy*
  • Obesity / blood
  • Obesity / physiopathology
  • Percutaneous Coronary Intervention
  • Prospective Studies
  • Self Report
  • Socioeconomic Factors

Substances

  • Adrenergic beta-Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents