TMEM106B and myelination: rare leukodystrophy families reveal unexpected connections

Brain. 2017 Dec 1;140(12):3069-3080. doi: 10.1093/brain/awx318.

Abstract

This scientific commentary refers to ‘A recurrent de novo mutation in TMEM106B causes hypomyelinating leukodystrophy’, by Simons et al. (doi:10.1093/brain/awx314).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Frontotemporal Lobar Degeneration*
  • Humans
  • Membrane Proteins / genetics
  • Mutation
  • Nerve Tissue Proteins / genetics*

Substances

  • Membrane Proteins
  • Nerve Tissue Proteins
  • TMEM106B protein, human