Invasive Aspergillus Pseudomembranous and Obstructive Tracheo-bronchitis in an Immuno-competent Patient

J Assoc Physicians India. 2017 Nov;65(11):92-93.

Abstract

A 19 year female, presented with life threatening haemoptysis and cough with minimum expectoration for 3 months. Bronchoscopy showed multiple nodules in airway. The direct microscopy and culture of sputum revealed fungal elements and Aspergillus flavus respectively. Serum Galactomannan was positive. Thus diagnosis of invasive aspergillus tracheo-bronchitis made. She responded to voriconazole. Aspergillus tracheo-bronchitis is a rare form of invasive pulmonary aspergillosis in immuno-competent host. Aspergillus spp in respiratory samples should not be routinely discarded as colonization.

Publication types

  • Case Reports

MeSH terms

  • Airway Obstruction / diagnosis
  • Airway Obstruction / etiology
  • Antifungal Agents / administration & dosage
  • Aspergillus* / isolation & purification
  • Aspergillus* / physiology
  • Bronchitis / microbiology*
  • Bronchitis / physiopathology
  • Bronchitis / therapy
  • Bronchoscopy / methods
  • Female
  • Galactose / analogs & derivatives
  • Hemoptysis* / diagnosis
  • Hemoptysis* / etiology
  • Hemoptysis* / physiopathology
  • Hemoptysis* / therapy
  • Humans
  • Invasive Pulmonary Aspergillosis* / complications
  • Invasive Pulmonary Aspergillosis* / diagnosis
  • Invasive Pulmonary Aspergillosis* / drug therapy
  • Invasive Pulmonary Aspergillosis* / physiopathology
  • Mannans / analysis
  • Mannans / blood
  • Sputum / microbiology*
  • Tracheitis / microbiology*
  • Tracheitis / physiopathology
  • Tracheitis / therapy
  • Treatment Outcome
  • Voriconazole / administration & dosage*
  • Young Adult

Substances

  • Antifungal Agents
  • Mannans
  • galactomannan
  • Voriconazole
  • Galactose