Impact of individual and neighborhood factors on disparities in prostate cancer survival

Mindy C DeRouen; Clayton W Schupp; Jocelyn Koo; Juan Yang; Andrew Hertz; Salma Shariff-Marco; Myles Cockburn; David O Nelson; Sue A Ingles; Esther M John; Scarlett L Gomez

doi:10.1016/j.canep.2018.01.003

Impact of individual and neighborhood factors on disparities in prostate cancer survival

Cancer Epidemiol. 2018 Apr:53:1-11. doi: 10.1016/j.canep.2018.01.003. Epub 2018 Jan 9.

Authors

Affiliations

¹ Cancer Prevention Institute of California, Fremont, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
² Cancer Prevention Institute of California, Fremont, CA, USA.
³ Cancer Prevention Institute of California, Fremont, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Health Research Policy (Epidemiology), Stanford University School of Medicine, Stanford, CA, USA.
⁴ Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
⁵ Cancer Prevention Institute of California, Fremont, CA, USA; Department of Health Research Policy (Epidemiology), Stanford University School of Medicine, Stanford, CA, USA.
⁶ Cancer Prevention Institute of California, Fremont, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: scarlett@cpic.org.

Abstract

Background: We addressed the hypothesis that individual-level factors act jointly with social and built environment factors to influence overall survival for men with prostate cancer and contribute to racial/ethnic and socioeconomic (SES) survival disparities.

Methods: We analyzed multi-level data, combining (1) individual-level data from the California Collaborative Prostate Cancer Study, a population-based study of non-Hispanic White (NHW), Hispanic, and African American prostate cancer cases (N = 1800) diagnosed from 1997 to 2003, with (2) data on neighborhood SES (nSES) and social and built environment factors from the California Neighborhoods Data System, and (3) data on tumor characteristics, treatment and follow-up through 2009 from the California Cancer Registry. Multivariable, stage-stratified Cox proportional hazards regression models with cluster adjustments were used to assess education and nSES main and joint effects on overall survival, before and after adjustment for social and built environment factors.

Results: African American men had worse survival than NHW men, which was attenuated by nSES. Increased risk of death was associated with residence in lower SES neighborhoods (quintile 1 (lowest nSES) vs. 5: HR = 1.56, 95% CI: 1.11-2.19) and lower education (<high school vs. college: HR = 1.32, 95% CI: 1.05-1.67), and a joint association of low education and low nSES was observed. Adjustment for behavioral, hospital, and restaurant and food environment characteristics only slightly attenuated these associations between SES and survival.

Conclusion: Both individual- and contextual-level SES influence overall survival of men with prostate cancer. Additional research is needed to identify the mechanisms underlying these robust associations.

Keywords: Built environment; Disparities; Education; Neighborhood socioeconomic status; Prostate cancer; Race/ethnicity; Survival.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Aged
Black or African American
California
Ethnicity
Hispanic or Latino
Humans
Male
Middle Aged
Prostatic Neoplasms / epidemiology*
Racial Groups
Registries
Residence Characteristics*
Social Class
Socioeconomic Factors*
White People

Abstract

Publication types

MeSH terms

Grants and funding