Use of antiviral medications in drug reaction with eosinophilia and systemic symptoms (DRESS): A case of infantile DRESS

Pediatr Dermatol. 2018 Mar;35(2):e114-e116. doi: 10.1111/pde.13408. Epub 2018 Jan 15.

Abstract

A 3-month-old girl with Sturge-Weber syndrome presented with a morbilliform rash, eosinophilia, and fulminant liver failure to our tertiary pediatric hospital. She was diagnosed with drug reaction with eosinophilia and systemic symptoms complicated by viremia and evidence of viral hepatitis on liver biopsy. We discuss the role of viral reactivation in drug reaction with eosinophilia and systemic symptoms and the relevance of antiviral therapy in management.

Keywords: cytomegalovirus; drug reaction with eosinophilia and systemic symptoms; drug reactions; human herpesvirus; viral reactivation.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Antiviral Agents / therapeutic use*
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus Infections / complications*
  • Drug Hypersensitivity Syndrome / complications
  • Drug Hypersensitivity Syndrome / diagnosis*
  • Drug Hypersensitivity Syndrome / therapy
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Infant
  • Methylprednisolone / therapeutic use
  • Sturge-Weber Syndrome / drug therapy

Substances

  • Anticonvulsants
  • Antiviral Agents
  • Glucocorticoids
  • Immunoglobulins, Intravenous
  • Methylprednisolone