Magnetoelectric nanoparticles for delivery of antitumor peptides into glioblastoma cells by magnetic fields

Nanomedicine (Lond). 2018 Feb;13(4):423-438. doi: 10.2217/nnm-2017-0300. Epub 2018 Jan 18.

Abstract

Aim: We studied externally controlled anticancer effects of binding tumor growth inhibiting synthetic peptides to magnetoelectric nanoparticles (MENs) on treatment of glioblastomas.

Methods: Hydrothermally synthesized 30-nm MENs had the core-shell composition of CoFe2O4@BaTiO3. Molecules of growth hormone-releasing hormone antagonist of the MIA class (MIA690) were chemically bound to MENs. In vitro experiments utilized human glioblastoma cells (U-87MG) and human brain microvascular endothelial cells.

Results: The studies demonstrated externally controlled high-efficacy binding of MIA690 to MENs, targeted specificity to glioblastoma cells and on-demand release of the peptide by application of d.c. and a.c. magnetic fields, respectively.

Conclusion: The results support the use of MENs as an effective drug delivery carrier for growth hormone-releasing hormone antagonists in the treatment of human glioblastomas.

Keywords: cancer/oncology; gene/drug delivery; nanoparticles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / chemistry*
  • Barium Compounds / chemistry
  • Brain / blood supply
  • Brain Neoplasms / drug therapy*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cobalt / chemistry
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Endothelial Cells / cytology
  • Endothelial Cells / drug effects
  • Ferric Compounds / chemistry
  • Glioblastoma / drug therapy*
  • Growth Hormone / antagonists & inhibitors*
  • Growth Hormone / metabolism
  • Hormone Antagonists / therapeutic use
  • Humans
  • Magnetic Fields
  • Magnetite Nanoparticles / chemistry*
  • Microvessels / cytology
  • Nanospheres / chemistry
  • Particle Size
  • Peptides / administration & dosage
  • Peptides / chemistry*
  • Titanium / chemistry

Substances

  • Antineoplastic Agents
  • Barium Compounds
  • Drug Carriers
  • Ferric Compounds
  • Hormone Antagonists
  • Magnetite Nanoparticles
  • Peptides
  • cobalt ferrite
  • barium titanate(IV)
  • Cobalt
  • Growth Hormone
  • Titanium