Abstract
Aim:
We studied externally controlled anticancer effects of binding tumor growth inhibiting synthetic peptides to magnetoelectric nanoparticles (MENs) on treatment of glioblastomas.
Methods:
Hydrothermally synthesized 30-nm MENs had the core-shell composition of CoFe2O4@BaTiO3. Molecules of growth hormone-releasing hormone antagonist of the MIA class (MIA690) were chemically bound to MENs. In vitro experiments utilized human glioblastoma cells (U-87MG) and human brain microvascular endothelial cells.
Results:
The studies demonstrated externally controlled high-efficacy binding of MIA690 to MENs, targeted specificity to glioblastoma cells and on-demand release of the peptide by application of d.c. and a.c. magnetic fields, respectively.
Conclusion:
The results support the use of MENs as an effective drug delivery carrier for growth hormone-releasing hormone antagonists in the treatment of human glioblastomas.
Keywords:
cancer/oncology; gene/drug delivery; nanoparticles.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / chemistry*
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Barium Compounds / chemistry
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Brain / blood supply
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Brain Neoplasms / drug therapy*
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Cell Line, Tumor
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Cell Survival / drug effects
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Cobalt / chemistry
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Drug Carriers / chemistry*
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Drug Liberation
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Endothelial Cells / cytology
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Endothelial Cells / drug effects
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Ferric Compounds / chemistry
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Glioblastoma / drug therapy*
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Growth Hormone / antagonists & inhibitors*
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Growth Hormone / metabolism
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Hormone Antagonists / therapeutic use
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Humans
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Magnetic Fields
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Magnetite Nanoparticles / chemistry*
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Microvessels / cytology
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Nanospheres / chemistry
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Particle Size
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Peptides / administration & dosage
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Peptides / chemistry*
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Titanium / chemistry
Substances
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Antineoplastic Agents
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Barium Compounds
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Drug Carriers
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Ferric Compounds
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Hormone Antagonists
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Magnetite Nanoparticles
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Peptides
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cobalt ferrite
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barium titanate(IV)
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Cobalt
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Growth Hormone
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Titanium