Abstract
Eight hours immobilization stress in young rats has increased the blood-brain barrier (BBB) permeability in 12 out of 14 brain regions studied. In the same regions cerebral blood flow (CBF) diminished by 2-37%, but the magnitude of flow reduction was not correlated with the degree of increased BBB permeability. On the other hand, a correlation was observed with increased plasma and brain 5-HT levels. The increased BBB permeability and increased 5-HT levels were prevented by pretreatment with p-CPA, indomethacin and diazepam. Cyproheptadine and vinblastine pretreatment prevented the occurrence of increased BBB permeability alone. The probable mechanism(s) underlying the breakdown of BBB permeability is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood-Brain Barrier* / drug effects
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Brain / blood supply*
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Brain / drug effects
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Cell Membrane Permeability* / drug effects
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Cyproheptadine / pharmacology
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Diazepam / pharmacology
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Female
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Fenclonine / analogs & derivatives
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Fenclonine / pharmacology
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Indomethacin / pharmacology
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Male
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Rats
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Rats, Inbred Strains
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Regional Blood Flow / drug effects
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Restraint, Physical
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Serotonin / metabolism*
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Serotonin Antagonists / pharmacology
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Stress, Physiological / drug therapy
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Stress, Physiological / physiopathology*
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Time Factors
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Vinblastine / pharmacology
Substances
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Serotonin Antagonists
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4-chlorophenylalanine methyl ester
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Cyproheptadine
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Serotonin
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Vinblastine
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Diazepam
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Fenclonine
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Indomethacin