Age of Infection with Kaposi Sarcoma-Associated Herpesvirus and Subsequent Antibody Values Among Children in Uganda

Pediatr Infect Dis J. 2018 Aug;37(8):e225-e228. doi: 10.1097/INF.0000000000001909.

Abstract

We investigated associations between Kaposi sarcoma-associated herpesvirus (KSHV) seroconversion age and KSHV antibody values in Ugandan children. Every annual delay in KSHV seroconversion age was associated with a reduction of 19% (P < 0.0001) in K8.1 and 27% (P < 0.0001) in ORF73 antibody values at 6 years of age. Early infection may be an important risk factor for KSHV pathogenesis and viral shedding in saliva, leading to transmission.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Antibodies, Viral / blood*
  • Child
  • Child, Preschool
  • Female
  • Herpesviridae Infections / epidemiology
  • Herpesviridae Infections / immunology*
  • Herpesvirus 8, Human*
  • Humans
  • Immunoglobulin G / blood*
  • Infant
  • Male
  • Risk Factors
  • Seroconversion
  • Uganda / epidemiology

Substances

  • Antibodies, Viral
  • Immunoglobulin G