RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis

Nat Plants. 2018 Mar;4(3):181-188. doi: 10.1038/s41477-017-0100-y. Epub 2018 Jan 29.

Abstract

Small RNAs regulate chromatin modifications such as DNA methylation and gene silencing across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24-nucleotide small interfering RNAs (siRNAs) that bind to ARGONAUTE 4 (AGO4) and target genomic regions for silencing. RdDM also requires non-coding RNAs transcribed by RNA polymerase V (Pol V) that probably serve as scaffolds for binding of AGO4-siRNA complexes. Here, we used a modified global nuclear run-on protocol followed by deep sequencing to capture Pol V nascent transcripts genome-wide. We uncovered unique characteristics of Pol V RNAs, including a uracil (U) common at position 10. This uracil was complementary to the 5' adenine found in many AGO4-bound 24-nucleotide siRNAs and was eliminated in a siRNA-deficient mutant as well as in the ago4/6/9 triple mutant, suggesting that the +10 U signature is due to siRNA-mediated co-transcriptional slicing of Pol V transcripts. Expression of wild-type AGO4 in ago4/6/9 mutants was able to restore slicing of Pol V transcripts, but a catalytically inactive AGO4 mutant did not correct the slicing defect. We also found that Pol V transcript slicing required SUPPRESSOR OF TY INSERTION 5-LIKE (SPT5L), an elongation factor whose function is not well understood. These results highlight the importance of Pol V transcript slicing in RNA-mediated transcriptional gene silencing, which is a conserved process in many eukaryotes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / metabolism*
  • Arabidopsis Proteins / metabolism*
  • Argonaute Proteins / metabolism
  • DNA Methylation*
  • DNA-Directed RNA Polymerases / metabolism*
  • Gene Silencing*
  • Genome-Wide Association Study
  • RNA, Guide, CRISPR-Cas Systems
  • RNA, Small Nuclear / metabolism*
  • Transcription, Genetic

Substances

  • AGO4 protein, Arabidopsis
  • AGO6 protein, Arabidopsis
  • AGO9 protein, Arabidopsis
  • Arabidopsis Proteins
  • Argonaute Proteins
  • RNA, Small Nuclear
  • RNA polymerase V, Arabidopsis
  • DNA-Directed RNA Polymerases