Bactericidal activity of ciprofloxacin against amikacin- and cefotaxime-resistant gram-negative bacilli and methicillin-resistant staphylococci

Antimicrob Agents Chemother. 1986 Jun;29(6):1098-100. doi: 10.1128/AAC.29.6.1098.

Abstract

The MICs and MBCs of ciprofloxacin were determined for clinical isolates of antibiotic-resistant aerobic bacteria. Decreased susceptibility to ciprofloxacin of cefotaxime- and amikacin-resistant Serratia marcescens and amikacin-resistant Pseudomonas aeruginosa strains were noted. The data suggest that ciprofloxacin susceptibility should be carefully monitored in treating patients with hospital-acquired bacterial infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amikacin / pharmacology*
  • Cefotaxime / pharmacology*
  • Ciprofloxacin
  • Cross Infection / microbiology
  • Gram-Negative Bacteria / drug effects*
  • Humans
  • Kanamycin / analogs & derivatives*
  • Methicillin / pharmacology*
  • Penicillin Resistance
  • Quinolines / pharmacology*
  • Staphylococcus / drug effects*

Substances

  • Quinolines
  • Kanamycin
  • Ciprofloxacin
  • Amikacin
  • Cefotaxime
  • Methicillin