Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia

Tomoaki Nakazono; Heechul Jun; Mathew Blurton-Jones; Kim N Green; Kei M Igarashi

doi:10.1016/j.neures.2018.02.002

Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia

Neurosci Res. 2018 Apr:129:40-46. doi: 10.1016/j.neures.2018.02.002. Epub 2018 Feb 10.

Authors

Tomoaki Nakazono¹, Heechul Jun¹, Mathew Blurton-Jones², Kim N Green³, Kei M Igarashi⁴

Affiliations

¹ Department of Anatomy and Neurobiology, University of California Irvine, United States; Center for the Neurobiology of Learning and Memory, University of California Irvine, United States.
² Department of Neurobiology & Behavior, University of California Irvine, United States; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, United States; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, United States.
³ Department of Neurobiology & Behavior, University of California Irvine, United States; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, United States.
⁴ Department of Anatomy and Neurobiology, University of California Irvine, United States; Center for the Neurobiology of Learning and Memory, University of California Irvine, United States; Japan Science and Technology Agency, Japan. Electronic address: kei.igarashi@uci.edu.

Abstract

Gamma oscillations that occur within the entorhinal cortex-hippocampal circuitry play important roles in the formation and retrieval of memory in healthy brains. Recent studies report that gamma oscillations are impaired in the entorhinal-hippocampal circuit of Alzheimer's disease (AD) patients and AD animal models. Here we review the latest advancements in studies of entorhinal-hippocampal gamma oscillations in healthy memory and dementia. This review is especially salient for readers in Alzheimer's research field not familiar with in vivo electrophysiology. Recent studies have begun to show a causal link between gamma oscillations and AD pathology, suggesting that gamma oscillations may even offer a plausible future therapeutic target.

Keywords: Alzheimer’s disease; Entorhinal cortex; Gamma oscillations; Hippocampus.

Publication types

Review

MeSH terms

Alzheimer Disease / physiopathology
Alzheimer Disease / psychology
Animals
Dementia / physiopathology*
Dementia / psychology*
Entorhinal Cortex / physiology*
Entorhinal Cortex / physiopathology
Gamma Rhythm*
Hippocampus / physiology*
Hippocampus / physiopathology
Humans
Memory*
Neural Pathways / physiopathology
Neurons / physiology

Abstract

Publication types

MeSH terms

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