To explore the association between sarcopenia (SAR) and long-term prognosis of patients with chronic heart failure (CHF) aged 70 years and over, 182 CHF patients from January 1, 2012 to December 31, 2014 were included in the present study. The patients were divided into the SAR group and the non-SAR group. The median follow-up period was 36 (3, 57) months. The endpoint was any heart failure-related event (HFRE). There were significant differences in age, body mass index, hemoglobin, B-type natriuretic peptide, hypersensitive troponin T (hs-TnT), left ventricular ejection fraction (LVEF) and cardiac function class between the two groups (all P<0.05). The Kaplan-Meier analysis showed that the survival time of the non-SAR patients was much longer than that of the SAR patients (P<0.05). The multivariate Cox regression analysis indicated that SAR was an independent risk factor for HFRE, suggesting a role of sarcopenia on long-term prognosis of patients with chronic heart failure.
为观察肌少症对70岁及以上慢性心力衰竭（CHF）患者远期预后的影响，对年龄≥70岁的182例CHF患者进行为期至少2年的随访，根据患者是否存在肌少症分为肌少症组和非肌少症组，记录一般临床资料。终点事件为心力衰竭相关事件(HFRE)。结果2组间年龄、体重指数、血红蛋白、B型利钠肽、超敏肌钙蛋白T、左心室射血分数和纽约心脏病协会(NYHA)心功能分级差异有统计学意义（P值均<0.05）。Kaplan-Meier曲线表明，肌少症组和非肌少症组无HFRE生存曲线差异有统计学意义（P<0.05）。多变量Cox比例风险回归分析证实肌少症为HFRE的独立危险因素。表明肌少症对CHF患者的远期预后存在显著影响。.
Keywords: Heart failure; Prognosis; Sarcopenia.