Matteson Homologation-Based Total Synthesis of Lagunamide A

Jan Gorges; Uli Kazmaier

doi:10.1021/acs.orglett.8b00576

Matteson Homologation-Based Total Synthesis of Lagunamide A

Org Lett. 2018 Apr 6;20(7):2033-2036. doi: 10.1021/acs.orglett.8b00576. Epub 2018 Mar 26.

Authors

Jan Gorges¹, Uli Kazmaier¹

Affiliation

¹ Saarland University , Organic Chemistry I , Campus, Bldg. C4.2 , D-66123 Saarbrücken , Germany.

PMID: 29578725
DOI: 10.1021/acs.orglett.8b00576

Abstract

Matteson homologation was found to be an excellent tool for the synthesis of the polyketide fragment of lagunamide A. Starting from a chiral boronic ester, a central building block containing all stereogenic centers of the polyketide chain was synthesized via six iterative Matteson homologation steps.

Publication types

Research Support, Non-U.S. Gov't