iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation

Shohei Komaki; Yuh Shiwa; Ryohei Furukawa; Tsuyoshi Hachiya; Hideki Ohmomo; Ryo Otomo; Mamoru Satoh; Jiro Hitomi; Kenji Sobue; Makoto Sasaki; Atsushi Shimizu

doi:10.1038/hgv.2018.8

iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation

Hum Genome Var. 2018 Mar 29:5:18008. doi: 10.1038/hgv.2018.8. eCollection 2018.

Authors

Shohei Komaki¹, Yuh Shiwa^{1

2

3}, Ryohei Furukawa¹, Tsuyoshi Hachiya¹, Hideki Ohmomo^{1

2}, Ryo Otomo^{1

2}, Mamoru Satoh^{1

2}, Jiro Hitomi^{4

5}, Kenji Sobue⁶, Makoto Sasaki^{5

7}, Atsushi Shimizu¹

Affiliations

¹ Division of Biomedical Information Analysis, Iwate Medical University, Shiwa, Iwate, Japan.
² Division of Biobank and Data Management, Iwate Medical University, Shiwa, Iwate, Japan.
³ Laboratory of Bioinformatics, Department of Molecular Microbiology, Faculty of Life Sciences, Tokyo University of Agriculture, Setagaya, Tokyo, Japan.
⁴ Department of Anatomy, School of Medicine, Institute for Biomedical Sciences, Iwate Medical University, Shiwa, Iwate, Japan.
⁵ Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Shiwa, Iwate, Japan.
⁶ Iwate Medical University, Morioka, Iwate, Japan.
⁷ Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Shiwa, Iwate, Japan.

Abstract

We launched an integrative multi-omics database, iMETHYL (http://imethyl.iwate-megabank.org). iMETHYL provides whole-DNA methylation (~24 million autosomal CpG sites), whole-genome (~9 million single-nucleotide variants), and whole-transcriptome (>14 000 genes) data for CD4⁺ T-lymphocytes, monocytes, and neutrophils collected from approximately 100 subjects. These data were obtained from whole-genome bisulfite sequencing, whole-genome sequencing, and whole-transcriptome sequencing, making iMETHYL a comprehensive database.