Response Expectancy and the Placebo Effect

Int Rev Neurobiol. 2018:138:81-93. doi: 10.1016/bs.irn.2018.01.003. Epub 2018 Feb 28.

Abstract

In this chapter, I review basic tenets of response expectancy theory (Kirsch, 1985), beginning with the important distinction between response expectancies and stimulus expectancies. Although both can affect experience, the effects of response expectancies are stronger and more resistant to extinction than those of stimulus expectancies. Further, response expectancies are especially important to understanding placebo effects. The response expectancy framework is consistent with and has been amplified by the Bayesian model of predictive coding. Clinical implications of these phenomena are exemplified.

Keywords: Automaticity; Placebo effects; Predictive coding; Response expectancy; Stimulus expectancy.

Publication types

  • Review

MeSH terms

  • Anticipation, Psychological / physiology*
  • Conditioning, Psychological / physiology*
  • Humans
  • Perception / physiology*
  • Placebo Effect*
  • Psychological Theory*