No association between 5 new GWAS-linked loci in Parkinson's disease and multiple system atrophy in a Chinese population

Neurobiol Aging. 2018 Jul:67:202.e7-202.e8. doi: 10.1016/j.neurobiolaging.2018.03.027. Epub 2018 Apr 3.

Abstract

Recently, 17 new Parkinson's disease (PD) risk loci were identified in a genome-wide association studies meta-analysis in Caucasians; however, their association with PD in Chinese patients is largely unknown. Therefore, we performed a replication study of 5 of the most commonly identified candidate variants, including SORBS3 rs2280104, SCN3A rs353116, TOX3 rs4784227, GLAC rs8005172, and ZNF184 rs9468199, in a large sample of patients with PD (1506) and multiple system atrophy (MSA, 496) in a Chinese population. These 5 variants were found to not be associated with PD and MSA in the Chinese population. Our results suggest that these variants are not risk factors for PD or MSA in the Chinese population.

Keywords: Association; Multiple system atrophy; Parkinson's disease; Variants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Apoptosis Regulatory Proteins
  • Asian People / genetics
  • Genetic Loci / genetics*
  • Genetic Variation
  • Genome-Wide Association Study*
  • High Mobility Group Proteins
  • Humans
  • Multiple System Atrophy / genetics*
  • Muscle Proteins
  • NAV1.3 Voltage-Gated Sodium Channel / genetics
  • Parkinson Disease / genetics*
  • Receptors, Progesterone / genetics
  • Risk Factors
  • Sodium Channels / genetics
  • Trans-Activators

Substances

  • Adaptor Proteins, Signal Transducing
  • Apoptosis Regulatory Proteins
  • High Mobility Group Proteins
  • Muscle Proteins
  • NAV1.3 Voltage-Gated Sodium Channel
  • Receptors, Progesterone
  • SCN3A protein, human
  • SORBS3 protein, human
  • Sodium Channels
  • TOX3 protein, human
  • Trans-Activators