Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Ying Guo; Hui Yang; Shi Chen; Peng Zhang; Rong Li; Stephen D Nimer; J William Harbour; Mingjiang Xu; Feng-Chun Yang

doi:10.1038/s41375-018-0126-9

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Leukemia. 2018 Aug;32(8):1834-1837. doi: 10.1038/s41375-018-0126-9. Epub 2018 Apr 2.

Authors

Ying Guo^{1

2}, Hui Yang^{1

2}, Shi Chen^{1

2}, Peng Zhang^{1

2}, Rong Li^{1

2}, Stephen D Nimer^{1

2}, J William Harbour^{1

2

3

4}, Mingjiang Xu^{5

6}, Feng-Chun Yang^{7

8}

Affiliations

¹ Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
² Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
³ Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
⁴ Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
⁵ Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. mxx51@miami.edu.
⁶ Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA. mxx51@miami.edu.
⁷ Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. fxy37@med.miami.edu.
⁸ Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA. fxy37@med.miami.edu.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Cell Transformation, Neoplastic
Gene Expression Regulation, Leukemic*
Humans
Leukemia, Experimental / genetics
Leukemia, Experimental / pathology
Leukemia, Experimental / prevention & control*
Leukemia, Myeloid / genetics
Leukemia, Myeloid / pathology
Leukemia, Myeloid / prevention & control*
Mice
Mice, Transgenic
Mutation*
Repressor Proteins / genetics
Repressor Proteins / metabolism*
Tumor Suppressor Proteins / deficiency*
Ubiquitin Thiolesterase / deficiency*

Substances

Asxl1 protein, mouse
BAP1 protein, mouse
Repressor Proteins
Tumor Suppressor Proteins
Ubiquitin Thiolesterase

Publication types

MeSH terms

Substances

Grants and funding