Past and Present: A Review of Antenatal Corticosteroids and Recommendations for Late Preterm Birth Steroids

C Luke Dixon; Gloria Too; George R Saade; Cynthia Gyamfi-Bannerman

doi:10.1055/s-0038-1653944

Past and Present: A Review of Antenatal Corticosteroids and Recommendations for Late Preterm Birth Steroids

Am J Perinatol. 2018 Nov;35(13):1241-1250. doi: 10.1055/s-0038-1653944. Epub 2018 May 23.

Authors

C Luke Dixon¹, Gloria Too², George R Saade¹, Cynthia Gyamfi-Bannerman³

Affiliations

¹ Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas.
² Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia.
³ Department of Obstetrics and Gynecology, Columbia University, New York, New York.

PMID: 29791953
DOI: 10.1055/s-0038-1653944

Abstract

Since 1972, the beneficial neonatal effects of antenatal corticosteroids (ACSs) have been repeatedly demonstrated in pregnancies at risk of preterm birth before 34 weeks' gestation. While ACS utilization before 34 weeks has been high since the 1990s, knowledge gaps regarding the risks and benefits of ACS continue to exist. Recent evidence has been published regarding the benefit of ACS in the late preterm period. This review addresses the evidence and knowledge gaps for ACS use before and after 34 weeks' gestation. We also provide recommendations for ACS use in the late preterm period.

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Publication types

Review

MeSH terms

Adrenal Cortex Hormones / pharmacology*
Female
Humans
Infant, Newborn
Pregnancy
Premature Birth / prevention & control
Prenatal Care* / methods
Prenatal Care* / trends
Prenatal Exposure Delayed Effects* / chemically induced
Prenatal Exposure Delayed Effects* / diagnosis
Risk Assessment

Substances

Adrenal Cortex Hormones