Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line

A Ardelt; R Carpenter; I Iwuchukwu; A Zhang; W Lin; E Kosciuczuk; C Hinkson; T Rebeiz; S Reitz; P King

doi:10.1016/j.dib.2017.10.033

Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line

Data Brief. 2017 Oct 17:16:1083-1090. doi: 10.1016/j.dib.2017.10.033. eCollection 2018 Feb.

Authors

A Ardelt¹, R Carpenter¹, I Iwuchukwu², A Zhang¹, W Lin¹, E Kosciuczuk³, C Hinkson¹, T Rebeiz¹, S Reitz¹, P King⁴

Affiliations

¹ Department of Neurology, University of Chicago, 5841 S. Maryland Ave, MC2030, Chicago, IL 60637, USA.
² Department of Neurocritical Care, Ochsner Medical Center, 1514 Jefferson Hwy., New Orleans, LA 70121, USA.
³ Division of Hematology-Oncology, Northwestern University, 675 North St. Clair, Chicago, IL 60611, USA.
⁴ Department of Neurology, University of Alabama at Birmingham, 1720 7th Sve South and the Birmingham VA Medical Center, Birmingham, AL 35233, USA.

Abstract

This set of experiments characterizes a model of transient cerebral ischemic stroke in a transgenic (Tg) mouse line in which the glial fibrillary acidic protein (GFAP) promoter is utilized to drive expression of a human RNA-binding protein, HuR. Additionally, the effect of cerebral ischemia on the expression of endogenous Hu proteins is presented.

Abstract

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