17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use

N Farzan; S J Vijverberg; N Hernandez-Pacheco; E H D Bel; V Berce; K Bønnelykke; H Bisgaard; E G Burchard; G Canino; J C Celedón; F T Chew; W C Chiang; M M Cloutier; E Forno; B Francis; D B Hawcutt; E Herrera-Luis; M Kabesch; L Karimi; E Melén; S Mukhopadhyay; S K Merid; C N Palmer; M Pino-Yanes; M Pirmohamed; U Potočnik; K Repnik; M Schieck; A Sevelsted; Y Y Sio; R L Smyth; P Soares; C Söderhäll; K G Tantisira; R Tavendale; S M Tse; S Turner; K M Verhamme; A-H Maitland-van der Zee

doi:10.1111/all.13499

17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use

Allergy. 2018 Oct;73(10):2083-2088. doi: 10.1111/all.13499. Epub 2018 Jul 9.

Authors

N Farzan^{1

2}, S J Vijverberg^{1

2}, N Hernandez-Pacheco^{3

4}, E H D Bel², V Berce^{5

6}, K Bønnelykke⁷, H Bisgaard⁷, E G Burchard⁸, G Canino⁹, J C Celedón¹⁰, F T Chew^{11

12}, W C Chiang¹², M M Cloutier¹³, E Forno¹⁰, B Francis¹⁴, D B Hawcutt^{14

15}, E Herrera-Luis⁴, M Kabesch¹⁶, L Karimi¹⁷, E Melén^{18

19}, S Mukhopadhyay^{20

21}, S K Merid¹⁸, C N Palmer²¹, M Pino-Yanes^{3

4

22}, M Pirmohamed²³, U Potočnik^{5

24}, K Repnik^{5

24}, M Schieck^{16

25}, A Sevelsted⁷, Y Y Sio^{11

12}, R L Smyth²⁶, P Soares²⁰, C Söderhäll^{27

28}, K G Tantisira^{29

30}, R Tavendale²¹, S M Tse³¹, S Turner³², K M Verhamme¹⁷, A-H Maitland-van der Zee^{1

2}

Affiliations

¹ Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
² Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
³ Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
⁴ Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Tenerife, Spain.
⁵ Centre for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
⁶ Clinic of Pediatrics, University Medical Centre Maribor, Maribor, Slovenia.
⁷ COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
⁸ Departments of Medicine, Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.
⁹ Behavioral Sciences Institute, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
¹⁰ Division of Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.
¹¹ Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
¹² The Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore, Singapore.
¹³ Asthma Center, Connecticut Children's Medical Center, University of Connecticut Health Center, Hartford, CT, USA.
¹⁴ Department of Women's and Children's Health, University of Liverpool, Liverpool, UK.
¹⁵ Alder Hey Children's Hospital, Liverpool, UK.
¹⁶ Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
¹⁷ Deptartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
¹⁸ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
¹⁹ Department of Pediatrics, Sachs' Children's Hospital, Stockholm, Sweden.
²⁰ Academic Department of Paediatrics, Brighton and Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK.
²¹ Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
²² CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
²³ Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
²⁴ Faculty for Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia.
²⁵ Department of Human Genetics, Hannover Medical School, Hannover, Germany.
²⁶ Institute of Child Health, University College London, London, UK.
²⁷ Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
²⁸ Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
²⁹ The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
³⁰ Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
³¹ Division of Respiratory Medicine, Department of Pediatrics, Sainte-Justine University Hospital Center and University of Montreal, Montreal, QC, Canada.
³² Child Health, University of Aberdeen, Aberdeen, UK.

Abstract

formula image

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Inhalation
Adrenal Cortex Hormones / administration & dosage*
Anti-Asthmatic Agents / administration & dosage
Asthma / drug therapy
Asthma / genetics*
Asthma / pathology
Chromosomes, Human, Pair 17 / genetics*
Disease Progression
Female
Humans
Male
Polymorphism, Single Nucleotide*
Treatment Failure

Substances

Adrenal Cortex Hormones
Anti-Asthmatic Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding