12-Hydroxyeicosatetraenoic acid levels are increased in actinic keratoses and squamous cell carcinoma

J Am Acad Dermatol. 2018 Dec;79(6):1152-1153. doi: 10.1016/j.jaad.2018.05.1251. Epub 2018 Jun 11.
No abstract available

MeSH terms

  • 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / analysis*
  • Biopsy
  • Carcinoma, Squamous Cell / chemistry*
  • Carcinoma, Squamous Cell / pathology
  • Celecoxib / pharmacology
  • Celecoxib / therapeutic use
  • Chemoprevention
  • Cyclooxygenase 2 / metabolism
  • Cyclooxygenase 2 Inhibitors / pharmacology
  • Cyclooxygenase 2 Inhibitors / therapeutic use
  • Glucuronosyltransferase / metabolism
  • Humans
  • Keratosis, Actinic / metabolism*
  • Keratosis, Actinic / pathology
  • Lipoxygenase Inhibitors / pharmacology
  • Lipoxygenase Inhibitors / therapeutic use
  • Neoplasms, Radiation-Induced / chemistry
  • Skin Neoplasms / chemistry*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / prevention & control

Substances

  • Cyclooxygenase 2 Inhibitors
  • Lipoxygenase Inhibitors
  • 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • UGT1A1 enzyme
  • Glucuronosyltransferase
  • Celecoxib