Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes

Marita Westhrin; Siv Helen Moen; Ida Bruun Kristensen; Glenn Buene; Anne Kærsgaard Mylin; Ingemar Turesson; Niels Abildgaard; Anders Waage; Therese Standal

doi:10.1186/s40364-018-0134-y

Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes

Biomark Res. 2018 Jun 14:6:21. doi: 10.1186/s40364-018-0134-y. eCollection 2018.

Authors

Marita Westhrin^{1

2}, Siv Helen Moen^{1

2}, Ida Bruun Kristensen³, Glenn Buene^{1

2}, Anne Kærsgaard Mylin⁴, Ingemar Turesson⁵, Niels Abildgaard³, Anders Waage^{1

6}, Therese Standal^{1

2

6}

Affiliations

¹ 1Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
² 2Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway.
³ 3Department of Hematology, Odense University Hospital, Odense, Denmark.
⁴ 4Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁵ 5Department of Hematology, Skane University Hospital, Malmo, Sweden.
⁶ 6Department of Hematology, St. Olav's University Hospital, Trondheim, Norway.

Abstract

Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.

Keywords: Adipocyte; Chemerin; Multiple myeloma; Stromal cell.