Abstract
Purpose of review:
This article provides a clinical review of the alternatives to traditional excisional surgical therapies for uterine leiomyomas, such as myomectomy or hysterectomy.
Recent findings:
In this review, currently available hormonal medications will be briefly discussed. Then, nonhormonal medical therapy will be addressed with respect to mechanism of action, safety, and efficacy. Finally, the risk-benefit profile of nonexcisional procedures for management of leiomyomas will be addressed.
Summary:
This provides an update on the information available for more conservative options for symptomatic leiomyoma management.
MeSH terms
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Antifibrinolytic Agents / therapeutic use
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Aromatase Inhibitors / therapeutic use
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Female
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Gonadotropin-Releasing Hormone / agonists
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Gonadotropin-Releasing Hormone / antagonists & inhibitors
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Humans
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Leiomyoma / therapy*
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Magnetic Resonance Imaging, Interventional
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Norpregnadienes / therapeutic use
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Radiofrequency Ablation
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Receptors, Progesterone / drug effects
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Tranexamic Acid / therapeutic use
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Ultrasonic Therapy
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Uterine Artery Embolization
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Uterine Neoplasms / therapy*
Substances
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Antifibrinolytic Agents
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Aromatase Inhibitors
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Norpregnadienes
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Receptors, Progesterone
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Gonadotropin-Releasing Hormone
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Tranexamic Acid
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ulipristal acetate