Neoantigens in Ovarian Cancer: Embarrassment of Riches or Needles in a Haystack?

Clin Cancer Res. 2018 Nov 15;24(22):5493-5495. doi: 10.1158/1078-0432.CCR-18-1731. Epub 2018 Jul 6.

Abstract

Comprehensive genomic and transcriptomic analysis demonstrate that tumor-infiltrating T lymphocytes that react to mutated neoepitopes could be identified in recurrent ovarian cancer. Two of these T-cell populations reacted against TP53 hotspot missense mutations that are present in a wide variety of malignancies. Clin Cancer Res; 24(22); 5493-5. ©2018 AACR See related article by Deniger et al., p. 5562.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Embarrassment*
  • Female
  • Humans
  • Lymphocytes, Tumor-Infiltrating
  • Mutation
  • Neoplasm Recurrence, Local
  • Ovarian Neoplasms*
  • Tumor Suppressor Protein p53 / genetics

Substances

  • TP53 protein, human
  • Tumor Suppressor Protein p53