GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI

Magn Reson Med. 2019 Jan;81(1):47-56. doi: 10.1002/mrm.27364. Epub 2018 Jul 29.

Abstract

Purpose: To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique.

Methods: The onVDMP method was applied for the detection of water signal changes upon venous D-glucose infusion in mice with 9L glioma xenografts. The effect size of onVDMP MRI during infusion was compared with that of conventional continuous wave (CW) CEST MRI.

Results: Both methods highlighted the tumor and the blood vessels on D-glucose infusion. In interleaved studies, the mean signal changes detected by onVDMP were found to be 1.8 times higher than those by CW-CEST, attributed to its high labeling efficiency for fast exchanging protons and the labeling of the OH protons over a larger frequency range.

Conclusions: The onVDMP method is a more sensitive technique for the detection of exogenous CEST agents with fast-exchanging protons compared to CW-CEST MRI.

Keywords: Chemical exchange; glioma; glucoCEST; on-resonance variable delay multiple pulse (onVDMP).

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Animals
  • Area Under Curve
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / pathology
  • Cell Line, Tumor
  • Contrast Media
  • Female
  • Glioma / diagnostic imaging*
  • Glioma / pathology
  • Glucose / metabolism
  • Image Interpretation, Computer-Assisted / methods
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Mice, SCID
  • Neoplasm Transplantation
  • Phantoms, Imaging
  • Protons
  • Reproducibility of Results
  • Spectrophotometry
  • Water

Substances

  • Contrast Media
  • Protons
  • Water
  • Glucose