Abstract
The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chelating Agents / chemistry
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Chelating Agents / isolation & purification
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Chelating Agents / metabolism
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Chelating Agents / pharmacology
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Leukemia P388 / drug therapy
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Leukemia P388 / pathology
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Magnetic Resonance Spectroscopy
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Mice
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Micromonosporaceae / metabolism*
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Mycolic Acids / analysis*
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Oxazoles / chemistry
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Oxazoles / isolation & purification
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Oxazoles / metabolism*
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Oxazoles / pharmacology
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Peptides / chemistry
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Peptides / isolation & purification
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Peptides / metabolism*
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Peptides / pharmacology
Substances
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Chelating Agents
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Mycolic Acids
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Oxazoles
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Peptides