Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal

PLoS Genet. 2018 Sep 6;14(9):e1007650. doi: 10.1371/journal.pgen.1007650. eCollection 2018 Sep.

Abstract

Adaptive evolution in humans has rarely been characterized for its whole set of components, i.e. selective pressure, adaptive phenotype, beneficial alleles and realized fitness differential. We combined approaches for detecting polygenic adaptations and for mapping the genetic bases of physiological and fertility phenotypes in approximately 1000 indigenous ethnically Tibetan women from Nepal, adapted to high altitude. The results of genome-wide association analyses and tests for polygenic adaptations showed evidence of positive selection for alleles associated with more pregnancies and live births and evidence of negative selection for those associated with higher offspring mortality. Lower hemoglobin level did not show clear evidence for polygenic adaptation, despite its strong association with an EPAS1 haplotype carrying selective sweep signals.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acclimatization / genetics*
  • Adult
  • Aged
  • Aged, 80 and over
  • Altitude
  • Asian People / genetics*
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Female
  • Genome-Wide Association Study
  • Haplotypes / physiology*
  • Hemoglobins / analysis
  • Humans
  • Middle Aged
  • Multifactorial Inheritance / physiology*
  • Nepal
  • Selection, Genetic / physiology*
  • Tibet

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Hemoglobins
  • endothelial PAS domain-containing protein 1

Associated data

  • Dryad/10.5061/dryad.bp46m
  • Dryad/10.5061/dryad.gc2n2