A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels

Biomark Med. 2019 Aug 1;13(11):931-940. doi: 10.2217/bmm-2017-0431. Epub 2018 Sep 7.

Abstract

Aim: The aim of the study was to explore the effects of variants at HMGCR-KIF6loci on a range of cardio-metabolic phenotypes. Methods: We analyzed the range of variants within Genetics in Brisighella Health Study and KIF6 genes using an additive genetic model on 18 cardiometabolic phenotypes in a sample of 1645 individuals from the Genetics in Brisighella Health Study and replicated in 10,662 individuals from the Estonian Genome Center University of Tartu. Results: We defined directly the effects of rs3846662:C>A at HMGCR on apoB levels. The analysis also confirmed effects of on low-density lipoprotein-cholesterol and total cholesterol levels. Variants in KIF6 gene did not reveal any associations with cardiometabolic phenotypes. Conclusion: This study highlights effect of HMGCR locus on assay-determined apoB levels, an infrequent measure of blood lipids in large studies.

Keywords: ApoB; blood lipids; cardiovascular disease.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Apolipoprotein B-100 / blood*
  • Cardiovascular Diseases / blood*
  • Cardiovascular Diseases / genetics*
  • Cholesterol, LDL / blood
  • Estonia
  • Female
  • Genetic Variation
  • Humans
  • Hydroxymethylglutaryl CoA Reductases / genetics*
  • Kinesins / genetics
  • Kinesins / metabolism
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Young Adult

Substances

  • APOB protein, human
  • Apolipoprotein B-100
  • Cholesterol, LDL
  • HMGCR protein, human
  • Hydroxymethylglutaryl CoA Reductases
  • KIF6 protein, human
  • Kinesins