Long-Term Engraftment (16 Years) of Myoblasts in a Human Infarcted Heart

Marie Crahès; Marie-Cécile Bories; Jean-Thomas Vilquin; Jean-Pierre Marolleau; Michel Desnos; Jérôme Larghero; Gilles Soulat; Patrick Bruneval; Albert A Hagège; Philippe Menasché

doi:10.1002/sctm.18-0017

Long-Term Engraftment (16 Years) of Myoblasts in a Human Infarcted Heart

Stem Cells Transl Med. 2018 Oct;7(10):705-708. doi: 10.1002/sctm.18-0017. Epub 2018 Sep 13.

Authors

Marie Crahès^{1

2}, Marie-Cécile Bories³, Jean-Thomas Vilquin⁴, Jean-Pierre Marolleau⁵, Michel Desnos^{2

6}, Jérôme Larghero^{7

8

9}, Gilles Soulat^{2

10}, Patrick Bruneval^{1

2

6}, Albert A Hagège^{2

6

11}, Philippe Menasché^{2

3

6}

Affiliations

¹ Department of Pathology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
² University Paris Descartes, Sorbonne Paris Cité, Paris, France.
³ Department of Cardiovascular Surgery, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
⁴ Sorbonne Université, INSERM, CNRS, Center of Research in Myology, Institute of Myology, GH Pitié-Salpêtrière, Paris, France.
⁵ CHU Amiens, Hematology and Cell Therapy Unit, Université Picardie Jules Verne, Amiens, France.
⁶ INSERM U970, Hôpital Européen Georges Pompidou, Paris, France.
⁷ Cell Therapy Unit, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, Cell Therapy Unit, Paris, France.
⁸ INSERM, CIC de Biothérapies (CBT-501) and U1160, Institut Universitaire d'Hématologie, Hôpital Saint-Louis, Paris, France.
⁹ University Paris Diderot, Sorbonne Paris Cité, Paris, France.
¹⁰ Department of Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
¹¹ Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.

Abstract

We report the case of a patient who had undergone injections of myoblasts in an infarct area 16 years before being referred for heart transplantation. The pathological examination of the explanted heart found persisting myotubes embedded in fibrosis. This finding supports the ability of myoblasts to survive in harsh environments, which can make them appealing candidates for transplantation in diseases requiring supply of new myogenic cells. Stem Cells Translational Medicine 2018;7:705-708.

Keywords: Clinical cell transplantation; Heart failure; Long-term follow-up; Myoblasts.

MeSH terms

Adult
Fibrosis
Humans
Male
Muscle Fibers, Skeletal / metabolism
Muscle Fibers, Skeletal / pathology
Muscle, Skeletal / metabolism
Muscle, Skeletal / pathology
Myoblasts, Skeletal / cytology
Myoblasts, Skeletal / metabolism
Myoblasts, Skeletal / transplantation*
Myocardial Infarction / pathology
Myocardial Infarction / therapy*
Myocardium / pathology
Myosin Heavy Chains
Troponin T / metabolism
Ventricular Function, Left / physiology

Substances

Troponin T
Myosin Heavy Chains