Abstract
The influence of Coxsackie B4 and AI3 viruses on the pancreas of mice (resistant and susceptible to diabetes) was studied. Glucose intolerance and changes in the synthesis of immunoreactive insulin were detected in all the treated groups of animals. Biochemical changes were more prominent in male DBA/2 mice, infected with Coxsackie B4 virus, in FI (CBA X C57Bl/6) hybrids and in female DBA/2 mice infected with Coxsackie AI3 virus and alloxan.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Blood Glucose / analysis
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Coxsackievirus Infections / blood
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Coxsackievirus Infections / complications*
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Diabetes Mellitus, Experimental / blood
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Diabetes Mellitus, Experimental / etiology*
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Disease Susceptibility
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Enterovirus
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Enterovirus B, Human
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Female
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Glucose Tolerance Test
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Immunity, Innate
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Insulin Antibodies / analysis
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Male
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Mice
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Mice, Inbred Strains
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Time Factors
Substances
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Blood Glucose
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Insulin Antibodies