Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

PLoS One. 2018 Dec 5;13(12):e0206684. doi: 10.1371/journal.pone.0206684. eCollection 2018.

Abstract

Purpose: The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma.

Method: A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined.

Results: A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes.

Conclusion: The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Diagnostic Errors*
  • Female
  • Glaucoma / diagnostic imaging*
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Retinal Ganglion Cells / pathology*
  • Tomography, Optical Coherence*

Grants and funding

This work was funded by a grant from National Health and Medical Research Council (NH&MRC- grant 1048037). JEC is funded by an NH&MRC Practitioner Fellowship (grant 1065433). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.