Case-control study investigating parameters affecting ventilator-associated events in mechanically ventilated patients

Aahd Kubbara; William R Barnett; Fadi Safi; Sadik Khuder; John Macko; Ragheb Assaly

doi:10.1016/j.ajic.2018.09.024

Case-control study investigating parameters affecting ventilator-associated events in mechanically ventilated patients

Am J Infect Control. 2019 Apr;47(4):462-464. doi: 10.1016/j.ajic.2018.09.024. Epub 2018 Dec 4.

Authors

Aahd Kubbara¹, William R Barnett², Fadi Safi¹, Sadik Khuder³, John Macko⁴, Ragheb Assaly¹

Affiliations

¹ Department of Internal Medicine, University of Toledo, Toledo, OH.
² Department of Internal Medicine, University of Toledo, Toledo, OH. Electronic address: william.barnett@utoledo.edu.
³ School of Population Health, University of Toledo, Toledo, OH.
⁴ Department of Pharmacy, University of Toledo, Toledo, OH.

PMID: 30522840
DOI: 10.1016/j.ajic.2018.09.024

Abstract

We analyzed a set of clinical parameters using Cox proportional hazard regressions to yield significant factors associated with the development of ventilator-associated events. In our study, intubation site, certain comorbidities, morphine, prednisone, and nutrition emerged as factors. Additionally, we presented potential mechanisms that require further research to validate.

Keywords: Critical care; Healthcare–associated infections; Risk factors; Surveillance; Time-to-event models.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Clinical Decision Rules*
Female
Humans
Male
Pneumonia, Ventilator-Associated / epidemiology*
Respiration, Artificial / adverse effects*
Risk Assessment