Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature

Lex M van Loon; Johannes G van der Hoeven; Joris Lemson

doi:10.1016/j.jcrc.2018.12.003

Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature

J Crit Care. 2019 Apr:50:138-143. doi: 10.1016/j.jcrc.2018.12.003. Epub 2018 Dec 5.

Authors

Lex M van Loon¹, Johannes G van der Hoeven², Joris Lemson²

Affiliations

¹ Biomedical Signals and Systems, Faculty of Electrical Engineering, Mathematics and Computer Science, Technical Medical Centre, University of Twente, Postbox 217, 7500 AE Enschede, the Netherlands; Department of Critical Care Medicine (707), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands. Electronic address: l.m.vanloon@utwente.nl.
² Department of Critical Care Medicine (707), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

PMID: 30540967
DOI: 10.1016/j.jcrc.2018.12.003

Abstract

The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.

Keywords: Heart failure; Hemodynamics; Microcirculation, V-A coupling; Septic shock; β-blocker.

Publication types

Review

MeSH terms

Adrenergic beta-Antagonists / pharmacology*
Animals
Critical Care
Critical Illness
Hemodynamics / drug effects*
Humans
Models, Animal
Sepsis / drug therapy*
Shock, Septic / drug therapy*

Substances

Adrenergic beta-Antagonists