Olfactory and cognitive functions in Chinese individuals at clinical high risk for psychosis

Ying He; Zongchang Li; Xiaoqian Ma; Liu Yuan; Lijun Ouyang; Jinsong Tang; Ming T Tsuang; Xiaogang Chen

doi:10.1016/j.psychres.2018.12.074

Olfactory and cognitive functions in Chinese individuals at clinical high risk for psychosis

Psychiatry Res. 2019 Feb:272:51-53. doi: 10.1016/j.psychres.2018.12.074. Epub 2018 Dec 14.

Authors

Ying He¹, Zongchang Li², Xiaoqian Ma², Liu Yuan², Lijun Ouyang², Jinsong Tang², Ming T Tsuang³, Xiaogang Chen⁴

Affiliations

¹ Department of Psychiatry, The Second Xiangya Hospital of Central South University, Renmin Road 139, Changsha, Hunan 410011, China; Center for Behavioral Genomics, Department of Psychiatry, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.
² Department of Psychiatry, The Second Xiangya Hospital of Central South University, Renmin Road 139, Changsha, Hunan 410011, China.
³ Center for Behavioral Genomics, Department of Psychiatry, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA; Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard School of Public Health, Boston, MA, USA.
⁴ Department of Psychiatry, The Second Xiangya Hospital of Central South University, Renmin Road 139, Changsha, Hunan 410011, China; Mental Health Institute of Central South University, Changsha, Hunan 410011, China; China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan 410011, China; China National Technology Institute on Mental Disorders, Changsha, Hunan 410011, China. Electronic address: chenxiaogang@csu.edu.cn.

PMID: 30579181
DOI: 10.1016/j.psychres.2018.12.074

Abstract

The abnormal olfactory function has been regarded as a sign in psychosis. To confirm the theory that olfactory and cognitive functions are deficient in Chinese cohort with clinical high risk state of psychosis, 19 individuals at clinical high risk for psychosis (CHRs) and 37 healthy controls (HCs) were recruited. The CHRs scored significantly lower than the HCs in the olfactory identification test and all other cognitive tests. Our findings suggest that olfactory dysfunction may be an early change of psychosis.

Keywords: Cognition; Olfaction; Psychosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
China
Cognitive Dysfunction / etiology
Cognitive Dysfunction / physiopathology*
Cohort Studies
Female
Humans
Male
Olfaction Disorders / etiology
Olfaction Disorders / physiopathology*
Psychotic Disorders / complications
Psychotic Disorders / physiopathology*
Risk
Young Adult