Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis

J Pediatric Infect Dis Soc. 2020 Feb 28;9(1):82-86. doi: 10.1093/jpids/piy141.

Abstract

We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis.

Keywords: MMP-2; MMP-9; TIMP-1; TIMP-2; cerebrospinal fluid; matrix metalloproteinase; pediatric; tissue inhibitors of metalloproteinase; tuberculous meningitis.

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Gelatinases
  • Humans
  • Infant
  • Male
  • Matrix Metalloproteinase 2 / blood
  • Matrix Metalloproteinase 2 / cerebrospinal fluid*
  • Matrix Metalloproteinase 9 / blood
  • Matrix Metalloproteinase 9 / cerebrospinal fluid*
  • Matrix Metalloproteinase Inhibitors / blood
  • Matrix Metalloproteinase Inhibitors / cerebrospinal fluid*
  • Prognosis
  • Reference Values
  • Statistics, Nonparametric
  • Tuberculosis, Meningeal / blood
  • Tuberculosis, Meningeal / cerebrospinal fluid*

Substances

  • Matrix Metalloproteinase Inhibitors
  • Gelatinases
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9